Critical dose of digoxin for treating supraventricular tachycardias after heart surgery.
نویسندگان
چکیده
This study was conducted to ascertain if critical peak body stores of digoxin were needed to protect patients from the debilities that result from supraventricular tachycardias occurring after open heart operations. We gave digoxin peak body stores of 15 micrograms/kg of lean body weight to 100 consecutive patients after open heart operations. If supraventricular tachycardias persisted four hours, we increased peak body stores to 17 or 19 micrograms/kg. The operations included coronary artery bypass grafts, heart valve replacements, and congenital defect correction. After operation, 18 patients had atrial fibrillation or flutter. During supraventricular tachycardias, ventricular rates were 150 beats per minute or slower. In the 100 patients, the median hospital stay after operation was four days. No patient required rehospitalization. The patients who had supraventricular tachycardias stayed in the hospital no longer than the patients who were at all times in regular sinus rhythm. All patients who entered the hospital with regular sinus rhythm went home with regular sinus rhythm. The critical safe peak body stores of digoxin needed to prevent debilities resulting from supraventricular tachycardias after open heart operations were 15 to 19 micrograms/kg of lean body weight.
منابع مشابه
Flecainide in the treatment of fetal tachycardias.
Fourteen mothers were treated with flecainide for fetal atrial tachycardias associated with intrauterine cardiac failure. Twelve of the 14 fetuses responded by conversion to sinus rhythm. One of the 12 fetuses subsequently died in utero. The remaining fetuses suffered no morbidity and were alive and well 3 months to 2 years after delivery. The two fetuses in whom atrial tachycardia did not conv...
متن کاملAtrial Tachycardias Occurring Late After Open Heart Surgery
Atrial tachycardias are common after open heart surgery. Most commonly these are macro-reentrant including cavotricuspid isthmus dependent atrial flutter, incisional right atrial flutter and left atrial flutter. Focal atrial tachycardias occur less frequently. The specific type of atrial tachycardia highly depends on the type of surgical incision. Catheter ablation can be very effective, howeve...
متن کاملDigoxin in the critically ill patient.
OBJECTIVE To review the pharmacodynamic and pharmacokinetic properties of digoxin in health and disease and the potential use and toxic effects of digoxin in the critically ill patient. DATA SOURCES A review of studies reported from 1966 to 1998 and identified through a MEDLINE search of the literature on digoxin and the use of digoxin in critical illness. SUMMARY OF REVIEW Digoxin inhibits...
متن کاملA Novel Criterion for Conduction Block after Catheter Ablation of Right Atrial Tachycardia after Mitral Valve Surgery Running title: Atrial tachycardias after mitral valve surgery
متن کامل
Cardiac arrhythmias: diagnosis and management. The tachycardias.
OBJECTIVE To review the diagnosis and management of cardiac arrhythmias in a two-part presentation. DATA SOURCES Articles and published peer-review abstracts on tachycardias and bradycardias. SUMMARY OF REVIEW Normal cardiac rhythm originates from impulses generated within the sinus node. These impulses are conducted to the atrioventricular node where they are delayed before they are distri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chest
دوره 95 4 شماره
صفحات -
تاریخ انتشار 1989